NO ONE saw the 49ers coming as possible No. 1 seed Bills the lone Must-Win squad | First Things First

Nick Wright unveils his NFL Tiers going into Week 18 and 2026, featuring the Jacksonville Jaguars, Buffalo Bills and San Francisco 49ers.
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Mahomes or Dak — Who Will Lead Their Offense to Victory? | First Things First

Danny Parkins, Wilie Colon, and Coach Eric Mangini break down the biggest QB matchups heading into Week 13. They debate Patrick Mahomes vs. Dak Prescott and Joe Burrow vs. Lamar Jackson, analyzing ...

Full-length Replay: First Things First: OT

The Herd with Colin Cowherd First Things First The Joel Klatt Show Kevin Harvick's Happy Hour Bear Bets ...
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49ers Back on Top? 'First Things First' Crew Predicts AFC, NFC West Winners

Both the NFC and AFC West could go any way this season. There's no questioning the talent and the coaching pedigree loaded in these two divisions. The Kansas City Chiefs and San Francisco 49ers met in ...