New open-source Python-based software boosts space-weather modeling

University of Birmingham experts have created open-source computer software that helps scientists understand how fast-moving ...
eLife

Molidustat Targets a Synthetic Lethal Vulnerability in APC-Mutant Colorectal Cancer through GSTP1 and PHD2 Co-Inhibition

This important paper substantially advances our understanding of how Molidustat may work, beyond its canonical role, by identifying its therapeutic targets in cancer. This study presents a compelling ...
eLife

Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation

EM, biochemical, and cell-based assays to examine how Gβγ interacts with and potentiates PLCβ3. The authors present evidence for multiple Gβγ interaction surfaces and argue that Gβγ primarily enhances ...
AHA/ASA Journals

Targeting Interleukin-8–Mediated Cellular Crosstalk Reverses Hypertrophic Cardiomyopathy and Cardiac Fibrosis in Noonan Syndrome

BACKGROUND: Genetic variants in components or regulators of the RAS-MAPK signaling pathway are causative for severe and early-onset hypertrophic cardiomyopathy (HCM) in patients with Noonan syndrome ...
Smithsonian Magazine

Could Python Blood Lead to the Next Generation of Weight-Loss Drugs?

Researchers discovered an appetite-suppressing molecule in python blood. If one day turned into a medication, it might lack ...
Virtualization Review

Running AI Natively on Windows 11 Using an eGPU

Tom Fenton reports running Ollama on a Windows 11 laptop with an older eGPU (NVIDIA Quadro P2200) connected via Thunderbolt dramatically outperforms both CPU-only native Windows and VM-based ...